Exposition au BPA et obésité

L’équipe du prof. Ana Soto publie une synthèse sur les connaissances sur le lien entre BPA et obésité. Les études in vitro montrent une différentiation des adipocytes, une accumulation lipidique, une action sur le transport du glucose et la sécrétion de l’adiponectine. Les études in vivo montrent une relation dose-dépendance sur le poids.

Source : Bisphenol A: Perinatal exposure and body weight.

Rubin BS, Soto A M. Mol Cell Endocrinol. 2009 May 25;304(1-2):55-62.

Lien : http://www.ncbi.nlm.nih.gov/pubmed/19433248?ordinalpos=3itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_

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Abstract :

Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed.